教师基本信息：

姓名：曹洪玉

职称：副教授，硕士生导师

所在学院：生命健康学院

电子邮箱：caohongyu@foxmail.com

个人简介：

男，博士，副教授，博士毕业于大连理工大学化工学院，2007年8月起到大连大学工作，辽宁省“百千万人才工程”千层次人才；大连市青年科技之星。现主持辽宁省教育厅项目1项，大连大学科研平台重点项目1项，大连市高层次人才项目1 项；主持完成国家自然科学青年基金1项，辽宁省教育厅科技项目1 项；主持教学改革课题4 项。承担《药物化学与合成》、《药物统计学》、《制药工程仿真综合训练》、《药物分子设计》等课程。指导完成国家级大学生创新创业计划项目3项，辽宁省大学生创新创业计划项目2项，指导本科生发表论文7篇。指导学生参加中国互联网+大赛等各级各类竞赛，获国家级奖1项，省级奖励6项；指导硕士研究生15 名，在国内外期刊上发表论文100余篇，其中SCIE、EI 收录论文60余篇（含JCR Q1论文2篇，Q2论文5篇）；获授权发明专利2 项。

研究方向：

开展蛋白-药物相互作用研究、金属蛋白结构功能研究及药物分子设计、药物分子模拟工作，运用激光闪光光解瞬态吸收光谱（纳秒级）、紫外、荧光、圆二色谱、电子顺磁共振等光谱实验并联用快速停流技术研究肌红蛋白、血红蛋白等铁卟啉蛋白的结构与功能，蛋白与小分子药物作用光谱学研究，采用分子对接、三维定量构效关系等方法分析和设计小分子药物，采用分子动力学方法模拟蛋白结构和模拟蛋白-药物作用模式。研究光催化分解抗生素等药物的机理。

一、近年主持的部分项目

二：近年代表性论文

[1] Hui Jiang, Mengdi Luo, Meina Gong, Ruisi Huang, Hongyu Cao*, Qian Tang, Lihao Wang, Ailing Wang, Baomin Feng, Xuefang Zheng, Biomaterial-based metal-phthalocyanine/metal oxide microspheres for photocatalytic degradation of organic pollutants under visible light, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023, 675, 132051, SCI JCR 2区

[2] Ruisi Huang, Hongyu Cao*, Ting Huang, Hongjiang Li, Qian Tang, Lihao Wang, Xuefang Zheng. Effects of environmental factors on the fleroxacin photodegradation with the identification of reaction pathways. Chemosphere. 2022, 308: 136373    SCI  JCR 1区

[3] Yafeng Jing, Anhe Wang, Jieling Li, Qi Li, Qingquan Han, Xuefang Zheng, Hongyu Cao*, Shuo Bai*.. Preparation of conductive and transparent dipeptide hydrogels for wearable biosensor. Bio-Design and Manufacturing. Bio-des. Manuf. (2022)5, 153–162. SCI  JCR 2区

[4] Yuqi Ma, Anhe Wang, Jieling Li, Qi Li, Qingquan Han, Yang Chen, Shengtao Wang, Xuefang Zheng, Hongyu Cao*, Shuo Bai*. Preparation of Hydroxyapatite with High Surface Area and Dispersity Templated on Calcium Carbonate in Dipeptide Hydrogels. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020. 124740      SCI  JCR  2区

[5] Hongyu Cao*, Meina Gong, Mengyan Wang, Qian Tang, Lihao Wang and Xuefang Zheng. Steady/transient state spectral researches on the solvent-triggered and photo-induced novel properties of metal-coordinated phthalocyanines. RSC Advances, 2022,12, 5964-5970    SCI  JCR 2区

[6] Hongyu Cao*, Ruisi Huang, Ting Huang, Qian Tang, Lihao Wang, Xuefang Zheng, The inner oxygen-substituted strategy effects on structure, aromaticity and absorption spectra of corrole isomers: A theoretical study, Journal of Molecular Graphics and Modelling, 2022, 112, 108118    SCI  JCR 2区

[7] Hong-Yu Cao*, Yu-Qi Ma, Ling-Xing Gao, Qian Tang, Xue-Fang Zheng*. Photo induced reaction of myoglobins with energy transferred from excited free tryptophan. RSC Advances, 2020,10, 43853-43858.    SCI  JCR 2区

[8] Hong-Yu Cao, Yan-Hua Wu, Xing-Zhi Zhou et al. In Silico Prediction and Validation of Oxygen- Regulated Protein N-myc Downstream Regulated Gene 3 and Virtual Screening of Competitive Inhibitors of L-Lactate as Therapeutics，Letters in Drug Design & Discovery. 2019,16 (6)：637-644 SCI   JCR 3区

[9] Hong-Yu Cao; Juan-Yuan Hao, Duan-Hui Sia; Qian Tang; Xuefang Zheng; Ce Hao. Theoretical Investigations on Electronic Structures and Absorption Spectra of Unsymmetrical Metal-coordinated Neo-confused Porphyrin in Various Solvents[J]. Chinese Journal of Structural Chemistry, 2018, 37(08): 1223-1232.       SCI  JCR 3区

[10] Wen-Qiong Zhang, Xiao-Jun Jin, Hong-Yu Cao*, Qian Tang, Ai-Ling Wang, Xue-Fang Zheng. Molecular structure and absorption spectral properties of Corrole Isomers: DFT and TDDFT-IEFPCM investigations. Computational and Theoretical Chemistry. 2018, 1140, 73-79   SCI  JCR 3区