一、基本信息

姓名：许玲

职称：副研究员

电子邮箱：dlxuling@163.com

二、个人简介

    许玲，女，博士，研究生导师，从事神经系统免疫性疾病的发病机制基础与临床研究，到目前为止仍将神经系统疾病作为科研工作的主攻方向，并发表多篇神经系统免疫疾病相关论文。主持辽宁省教育厅基金一项，大连市卫生局基金一项，大连市高层次人才支持项目基金一项，大连大学学科交叉项目一项。入选辽宁省“百千万人才工程”千层次。获得大连市“青年科技之星”称号。获得大连市科学技术进步奖二等奖，辽宁省自然科学学术成果奖学术论文奖二等奖。

三、研究方向

    海洋寡糖活性的研究；多发性硬化、阿尔茨海默病、重症肌无力、缺血性脑卒中等神经免疫相关疾病的发病机制及防治；肠道菌群与代谢类疾病研究。

四、代表性论文

1、Yao Zi-ang*, Xu Ling*, Wang Bai-xiang, Ye Ting-ting, Li Yan-feng, Wu Hai-ge#. Optimization of preparation conditions, molecular structure analysis and antitumor activity of sulfated sodium alginate oligosaccharides. European Polymer Journal. 2023 (201): 112571.

2、Xu Ling, Ren He, Xie Daqing, Zhang Feng, Hu Xiaoxiao, Fang Shu, Wang Hongli d, He Dan#. Rac2 mediate foam cell formation and associated immune responses in THP-1 to promote the process of atherosclerotic plaques. Molecular Immunology. 2023, 163: 196-206.

3、Haojian Sun*, Ling Xu*, Kangkang Wang, Yanfeng Li, Tongning Bai, Shuo Dong, Haige Wu#, Ziang Yao#. κ-Carrageenan Oligosaccharides Protect Nerves by Regulating Microglial Autophagy in Alzheimer’s Disease. ACS Chemical Neuroscience. 2023, 14: 3540-3550.

4、Yao Zi-ang^*, Xu Ling^*, Jin Li-ming, Wang Tian-sheng, Wang Bai-xiang, Li Jiang-zhou, Bai Ying, Wu Hai-ge^#. κ-Carrageenan oligosaccharides induce microglia autophagy through AMPK/ULK1 pathway to regulate their immune response. International Journal of Biological Macromolecules. 2022, 194: 198-203.

5、Xu Ling, He Dan, Zhang Changlin, Bai Ying, Zhang Cuili^#. The regulate function of polysaccharides and oligosaccharides that with sulfate group on immune-related disease. Journal of Functional Foods. 2022, 88: 104870.

6、Yao Zi-ang ^*, Xu Ling ^*, Jin Li-ming, Wang Bai-xiang, Fu cheng-zhu, Bai Ying, Wu Hai-ge^#. κ-Carrageenan Oligosaccharides Inhibit the Inflammation of Lipopolysaccharide-Activated Microglia Via TLR4/NF-κB and p38/JNK MAPKs Pathways. Neurochemical Research. 2022, 47 (2): 295-304.

7、Xu Ling，Zhang Cuili，He Dan，Jiang Nan，Bai Ying，Xin Yi^#. Rapamycin and MCC950 Modified Gut Microbiota in Experimental Autoimmune Encephalomyelitis Mouse by Brain Gut Axis. Life Sciences. 2020, 253: 117747.

8、Xu Ling，Zhang Cuili，Jiang Nan，He Dan，Bai Ying，Xin Yi^#. Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis. Journal of Cellular Biochemistry. 2019, 120(4): 5160-5169.