姓名：李子彬
学历：博士
职称：讲师
Email：lzb3250797@126.com
办公地点：问源楼A座一楼
个人简历:
李子彬，男，1989年出生，汉族，博士，讲师，硕士研究生导师，大连市高层次人才-青年才俊（大人才办发 [2021] 13号）。主持国家自然科学基金青年项目1项（No. 32102828,），参与国家自然科学基金面上项目2项（No. 32170549; No. 31972683），参与辽宁省重点实验室项目（No. LZ2015003）1项；参与大连大学学科建设专项-学科交叉重项目1项；目前发表SCI文章14篇。
主要研究领域或方向
1. 利用X射线晶体学手段探究细胞免疫核心分子——MHC I/II类分子呈递抗原表位的分子机制，筛选优势抗原表位，助力畜禽养殖高发病原的表位疫苗开发。
2. 利用蛋白工程（真原核表达系统、蛋白纯化）和结构生物（X射线晶体学、冷冻电镜三维重构）手段 “理性设计”指导酶分子改造以及亚单位疫苗开发。
学术与科研项目：
(1) 国家自然科学基金委员会, 青年科学基金项目, 32102828, 长江系野生草鱼MHC I递呈不同基因型草鱼呼肠孤病毒多肽的分子机制研究, 2022-01-01 至 2023-12-31, 20万元, 结题, 主持
(2) 国家自然科学基金委员会, 面上项目, 32170549, TopBP1参与ATR通路DNA损伤修复的相互作用分子机理研究, 2022-01-01 至 2025-12-31, 58万元, 在研, 参与；
(3) 国家自然科学基金委员会, 面上项目, 31972683, 鸡MHC-II表位肽识别与免疫调节机理的研究, 202001-01 至 2023-12-31, 57万元, 结题 参与；
(4) 大连大学学科建设专项, 学科交叉重项目, 青少年特发性脊柱侧凸早期诊断和干预, 2023-01-01 至 2024-12-31, 30万元, 在研, 参与；
工作经历：
2008.09—2012.08 吉林农业大学，食品科学与工程学院，本科
2012.09—2015.08 吉林农业大学，生命科学学院，硕士
2015.09—2019.06 中国农业大学，动物医学院，博士
2019.11—2020.01 中科院天津工业生物技术研究所，助理研究员
2020.01—2021.11 南开大学，药学院，博士后
2021.11—2023.03 天津农学院，动物科学与动物医学院
2023.05— 大连大学，生命健康学院
教学工作：
《免疫学》（普通高校本科生）
《疫苗学》（普通高校本科生）
《分子遗传与表观遗传》（硕士生）
《分子免疫与技术开发》（硕士生）
论文及成果：
1. Xingyao Pei; Dingkuo Liu; Jianjun Li; Liuan Li; Xiangbin Ding; Wenjuan Zhang; Zibin Li; Gang Xu; Cun Li; Daowen Li. TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles. Science of The Total Environment, 2023, 865:161242.
2. Song Jinxing; Wang Mengxiang; Zhang Yixuan; Wan Bo; Du Yongkun; Zhuang Guoqing; Li Zibin; Qiao Songlin; Geng Rui; Wu Yanan; Zhang Gaiping. Identification and epitope mapping of anti-p72 single-chain antibody against African swine fever virus based on phage display antibody library. Journal of Integrative Agriculture, 2023, 22(9): 2834-2847.
3. Lei Feng; Yong-Yu Gao; Mingwei Sun; Zi-Bin Li; Qiang Zhang; Jie Yang; Cui Qiao; Hang Jin; Hong-Sheng Feng; Yu-Han Xian; Jianxun Qi; George F. Gao; William J. Liu; Feng-Shan Gao. The Parallel Presentation of Two Functional CTL Epitopes Derived from the O and Asia 1 Serotypes of Foot-and-Mouth Disease Virus and Swine SLA-2HB01: Implications for Universal Vaccine Development. Cells, 2022, 11(24): 4017.
4. Peiyuan Liu; Yanfeng Zhang; Zibin Li; Jianwen Huang; Tao Wang; Cheng Chen. Structural insights revealed by crystal structure of B38-CAP, an isoenzyme of carboxypeptidase ACE2, the receptor of SARS-CoV-2.Biochemical and Biophysical Research Communications, 2022, 606: 17-22.
5. Li Zibin#; Zhang Nianzhi#; Ma Lizhen; Zhang Lijie; Meng Geng; Xia Chun*. The mechanism of beta-2m molecule-induced changes in the peptide presentation profile in a bony fish. iScience, 2020, 23(5):101119.
6. Li Zibin; Zhang Nan; Ma Lizhen; Qu Zehui; Wei Xiaohui; Liu Zixin; Tang Minghu; Zhang Nianzhi; Jiang Yinan; Xia Chun*; Distribution of ancient alpha1 and alpha2 domain lineages between two classical MHC class I genes and their alleles in grass carp. Immunogenetics, 2019, 71(5-6):395-405.
7. Sun Jixue#; Li Zibin#; Yang Na*. Mechanism of the Conformational Change of the Protein Methyltransferase SMYD3: A Molecular Dynamics Simulation Study. International journal of molecular sciences, 2021, 22(13):7185.
8. Qu Zehui#; Li Zibin#; Ma Lizhen; Wei Xiaohui; Zhang Lijie; Liang Ruiying; Meng Geng; Zhang Nianzhi; Xia Chun*; Structure and Peptidome of the Bat MHC Class I Molecule Reveal a Novel Mechanism Leading to High-Affinity Peptide Binding. Journal of immunology, 2019, 202(12):3493-3506.
9. Chen Xiaoqing #; Li Zibin#; Hu Guixue; Gu SongZhi; Zhang Shuang; Ying Ying; Gao Fengshan*; Isolation, Identification, and Sequencing of a Goose-Derived Newcastle Disease Virus and Determination of Its Pathogenicity. Avian diseases, 2015, 59(2): 235-244.
10. Duan, Yulu; Wang, Yawen; Li, Zibin; Ma, Lizhen; Wei, Xiaohui; Yang, Junqi; Xiao, Ruiqi; Xia, Chun*. The unique structure of the zebrafish TNF-α homotrimer. Developmental & Comparative Immunology, 2021, 122:104129.
11. Wei, Xiaohui; Wang, Song; Li, Zhuolin; Li, Zibin; Qu, Zehui; Wang, Suqiu; Zou, Baohua; Liang, Ruiying; Xia, Chun; Zhang, Nianzhi*. Peptidomes and Structures Illustrate Two Distinguishing Mechanisms of Alternating the Peptide Plasticity Caused by Swine MHC Class I Micropolymorphism. Frontiers in Immunology, 2021, 12:592447.
12. Feng Lei; MingWei Sun; Ping Jiang; Zibin Li; Hua Gao; Xiaoxin Zhai; Yong Han; Zonghui Zhang; Fengshan Gao*. Purification, crystallization and preliminary X-ray crystallographic studies of swine MHC class I complexed with an FMDV CTL epitope Hu64. Research in veterinary science, 2018, 19: 205-208.
13. Fengshan Gao*; Xiaoxin Zhai; Ping Jiang; Qiang Zhang; Hua Gao; Zibin Li; Yong Han; Jie Yang; Zonghui Zhang. Identification of two novel foot-and-mouth disease virus cytotoxic T lymphocyte epitopes that can bind six SLA-I proteins. Gene, 2018, 653: 91-101.
14. Liang Ruiying #; Sun Yaping #; Liu Yanjie; Wu Yanan; Li Zibin; Ma Lizhen; Zhang Nan; Zhang Lijie; Qu Zehui; Zhang Nianzhi*; Xia Chun*; Major Histocompatibility Complex Class I (FLA-E*01801) Molecular Structure in Domestic Cats Demonstrates Species-Specific Characteristics in Presenting Viral Antigen Peptides. Journal of virology, 2018, 92(6): e01631-17.
15. 李子彬; 董宋鹏; 杨杰; 高凤山; 胡薇*; MHC II类四聚体技术研究进, 生命科学, 2014, 26(10): 1096-1101.
