基本资料
姓名：王新一
职称：教授
电子邮件：wangxinyi@dlu.edu.cn
联系地址：大连开发区学府大街10号大连大学
个人简介
王新一，男，教授，研究生导师。2014年在北京大学化学生物学专业获得博士学位，之后在国家纳米科学中心和德国马尔堡大学从事博士后研究和学术访问，现任大连大学生命健康学院生物技术学科方向带头人，组建了先进材料与生物医学研究团队，建立了较为成熟的多学科交叉研究技术平台，以国家和社会重大科技需求为导向，致力于解决纳米科学、生物医学、现代农业相关领域的重要科学问题和关键技术难题。主持和参与国家重点研发计划、国家基金委、省市级科研项目14项；授权发明专利19项；在国内外重要学术期刊发表论文60篇。
研究方向
课题组主要结合纳米技术、材料、化学、药学、合成生物学、计算模拟等多元化分析手段，研究纳米生物界面相互作用的基本规律，促进新型纳米材料在生物医学领域的应用。主要从事的研究方向包括：（1）纳米-生物界面及其化学生物效应分析；（2）新型纳米生物传感技术开发与应用；（3）生物医学材料功能化设计及其在生物医学领域应用。
代表性论文
1) Xinyi Wang#, Di Zhang#, Ning Jiang, Xiaofeng Wang, Naiwen Zhang, Kai Zhang, Xiaoyu Sang, Ying Feng, Ran Chen, Na Yang, Qijun Chen. Induction of apoptosis in Trypanosoma brucei following endocytosis of ultra-small noble metal nanoclusters. Nano Today, 2021,38: 101122. (IF = 18.96)
2) Xinyi Wang, Xiaofeng Wang, Xuan Bai, Liang Yan, Tao Liu, Mingzhe Wang, Youtao Song, Guoqing Hu, Zhanjun Gu, Qing Miao, Chunying Chen*. Nanoparticle Ligand Exchange and Its Effects at the Nanoparticle−Cell Membrane Interface. Nano Letters, 2019, 19(1): 8-18. (IF = 12.26)
3) Xinyi Wang#, Xiaofeng Wang#, Mingzhe Wang, Di Zhang, Tao Liu, Rong Lei, Shuifang Zhu, Yuliang Zhao, Chunying Chen*. Probing Adsorption Behaviors of BSA onto Chiral Surfaces of Nanoparticles. Small 2018, 14(16): 1703982. (IF = 15.15)
4) Xinyi Wang#, Mingzhe Wang#, Rong Lei, Shui fang Zhu, Yuliang Zhao, Chunying Chen*. Chiral surface of nanoparticles determines the orientation of adsorbed transferrin and its interaction with receptors. Acs Nano, 2017, 11: 4606-4616.（IF = 18.02）
5) Xinyi Wang#, Yiwei Xie#, Ning Jiang, Jingyi Wang, Hongrui Liang, Dingyuan Liu, Na Yang, Xiaoyu Sang, Ying Feng, Ran Chen, Qijun Chen. Enhanced antimalarial efficacy obtained by targeted delivery of artemisinin in heparin-coated magnetic hollow mesoporous nanoparticles. ACS Applied Materials & Interfaces, 2021, 13: 287-297. (IF = 10.38)
6) Xiaofeng Wang#, Rong Lei#, Limei Li#, Xinyu Fei, Rui Ju, Xiwen Sun, Huiying Cao, Qingfang Zhang*, Chunying Chen*, and Xinyi Wang*. Rearrangement of protein structures on a gold nanoparticle surface is regulated by ligand adsorption modes. Nanoscale封面, 2021, 13: 20425-20436.（IF =8.307）
7) Rong Lei, Pinshan Wu, Limei Li, Qunxing Huang, Jingyi Wang, Di Zhang, Mingfu Li, Naizhong Chen*, Xinyi Wang*. Ultrasensitive isothermal detection of a plant pathogen by using a gold nanoparticle-enhanced microcantilever sensor. Sensors & Actuators: B. Chemical, 2021, 338: 129874. (IF = 9.22)
8) Xinyi Wang, Mingjian Zou, Hongduan Huang, Yuqian Ren, Limei Li, Xiaoda Yang, Na Li*. Gold nanoparticle enhanced fluorescence anisotropy for the assay of single nucleotide polymorphisms (SNPs) based on toehold-mediated strand-displacement reaction. Biosensors & Bioelectronics, 2013, 41: 569-575.（IF=12.54）
9) Rong Lei, Jun Kong, Yanhong Qiu, Naizhong Chen, Shuifang Zhu, Xinyi Wang* and Pinshan Wu*. Rapid detection of the pathogenic fungi causing blackleg of Brassica napus using a portable real-time fluorescence detector. Food Chemistry, 2019, 288: 57-67. (IF = 9.23)
10) Rong Lei, Yuan Li, Limei Li, Jingyi Wang, Rui Ju, Li Jiang, Xiaoling Liao*, Pinshan Wu*, Xinyi Wang*. A CRISPR/Cas12a-based portable platform for rapid detection of Leptosphaeria maculans in Brassica crops. Frontiers in plant science, 2022, 13: 976510. （IF = 6.627）
11) Xiwen Sun #, Rong Lei#, Haipeng Zhang, Wujian Chen, Qianwen Jia, Xing Guo, Yongjiang Zhang, Pinshan Wu, Xinyi Wang*. Rapid and sensitive detection of two fungal pathogens in soybeans using the recombinase polymerase amplification/CRISPR-Cas12a method for potential on-site disease diagnosis. Pest Management Science, 2024, 80:1168-1181.（IF=4.463）
12) Xiaofeng Wang#, Yanglin Hu#, Limei Li#, Rui Ju, Xiaofei Han, Haihui Tan, Xiaoxi Ruan, Rong Lei, Na Wang, Jingyi Wang*, Xinyi Wang*. Acetylenic Bond Layout Drives the Directional Assembly of Amyloid-like Peptides on Graphyne: Implications for Biomedical Safety Applications of Graphyne. ACS Applied Nano Materials, 2023, DOI: 10.1021/acsanm.3c00413.（IF=4.463）
13) Rong Lei, Weijun Duan, Xinyi Wang*, Pinshan Wu*. Nanopore/Illumina Hybrid Whole-genome Sequence Resource of Plenodomus lindquistii Strain US01 Infecting Sunflower. Plant Disease, 2022, MEDLINE: 36510424.（IF=4.614）
14) Rong Lei#, Limei Li#, Pinshan Wu, Xinyu Fei, Yuting Zhang, Jingyi Wang, Di Zhang, Qingfang Zhang*, Na Yang*, and Xinyi Wang*. RPA/CRISPR/Cas12a-Based On-Site and Rapid Nucleic Acid Detection of Toxoplasma gondii in the Environment. Acs Synthetic Biology, 2022, 11, 1772-1781.（IF=5.249）
15) Xinyi Wang#, Na Wang#, Limei Li, Ruyue Xiao, Lan Yuan, Xiaoda Yang*, Na Li. Evaluation of red and near infrared fluorescent silver nanoclusters as potential in vivo indicators of tight junction opening. RSC Advances, 2017, 7: 32536-32542.（IF=4.036）
16) Xinyi Wang, Rong Lei, Lan Yuan*, Na Wang, Ruyue Xiao, Lidan Bai, Xue Li, Limei Li, Xiaoda Yang*. The permeability and transport mechanism of graphene quantum dots (GQDs) across the biological barrier. Nanoscale, 2015, 7: 2034-2041.（IF=8.307）
17) Xinyi Wang#, Ruoyun Lin#, Hongduan Huang, Limei Li, Feng Liu, Na Li*, Xiaoda Yang*. N-acetylcysteine induced quenching of red fluorescent oligonucleotide-stabilized silver nanoclusters and the application in pharmaceutical detection. Analytica Chimica Acta, 2013, 793: 79-85.（IF=6.911）
18) Xinyi Wang, Yao Xu, Xiao Xu, Ke Hu, Minghui Xiang, Limei Li, Feng Liu, Na Li*. Direct Determination of Urinary Lysozyme Using Surface Plasmon Resonance Light-Scattering of Gold Nanoparticles. Talanta, 2010, 82: 693-697.（IF=5.339）
