姓名：姜熙

职称：讲师

电子邮箱：jiangxi@dlu.edu.cn

办公地点：生命健康学院B座3楼

办公电话：

个人简介：男，1990年出生，博士，2020年毕业于大连理工大学生物工程学院生物化工系，2020-2023年在中国农业科学院农业基因组研究所从事博士后研究。2023年12月加入大连大学生命健康学院生物技术系，专任教师。

研究方向：生物化学和结构生物学，通过对生命过程中关键蛋白的活性表征和三维结构解析，揭示蛋白质结构与功能关系，通过基于结构的虚拟筛选获得高活性小分子化合物并阐明作用机制，为药物设计提供理论依据。近五年研究成果发表于Journal of Medicinal Chemistry、Journal of Agricultural and Food Chemistry、Bioorgnic Chemistry等SCI期刊。

代表性论文：

[1] Xi Jiang, Qing Yang^*. Recent advances in glycoside hydrolase family 20 and 84 inhibitors: structures, inhibitory mechanisms and biological activities. Bioorganic Chemistry. 2024, 144:107160.

[2] Xi Jiang^#, Ashutosh Kumar^#, Yasutaka Motomura, Tian Liu, Yong Zhou, Kazuyo Moro, Kam Y.J. Zhang^*, Qing Yang^*. A series of compounds bearing a dipyrido-pyrimidine scaffold acting as novel human and insect pest chitinase inhibitors. Journal of Medicinal Chemistry, 2020, 63: 987-1001.

[3] Xi Jiang^#, Ashutosh Kumar^#, Tian Liu, Kam Y.J. Zhang^*, Qing Yang^*. A novel scaffold for developing specific or broad-spectrum chitinase inhibitors. Journal of Chemical Information and Modeling, 2016, 56: 2413-2420.

[4] Xi Jiang, Han Bao, Hans Merzendorfer, Qing Yang. Immune responses of mammals and plants to chitin-containing pathogens. Targeting Chitin-containing Organisms. Springer, Singapore, 2019, 61-81.

[5] Lili Dong^#,*, Shengqiang Shen^#, Xi Jiang^#, Baokang Ding, Meiling Yang, Wei Chen, Yaxin Liu, Ziyang Chen, Qingnan Cao, Yongming Gao, Shujie Ma, Lihui Zhang^*, Jingao Dong^*, Qing Yang^*. Identification of triazolo-quinazolinone derivatives as novel and potent chitinase OfChi-h inhibitors based on structure-based virtual screening. Journal of Agricultural and Food Chemistry. 2023, 71(45), 17410–17419.

[6] Lili Dong^#,*, Shengqiang Shen^#, Xi Jiang^#, Yaxin Liu, Jingjing Li, Wei Chen, Yizhen Wang, Jiakun Shi, Jiaxin Liu, Shujie Ma, Lihui Zhang^*, Jingao Dong^*, Qing Yang^*. Discovery of azo-aminopyrimidines as novel and potent chitinase OfChi-h inhibitors via structure-based virtual screening and rational lead optimization. Journal of Agricultural and Food Chemistry, 2022, 70(38): 12203-12210.

[7] Huitang Qi^#, Xi Jiang^#, Yi Ding, Tian Liu^*, Qing Yang^*. Discovery of kasugamycin as a potent inhibitor of glycoside hydrolase family 18 chitinases. Frontiers in Molecular Biosciences. 2021, 8:640356.

[8] Pengtao Yuan^#, Xi Jiang^#, Siyu Wang, Xusheng Shao, Qing Yang^*, Xuhong Qian^*. X-ray structure and molecular docking guided discovery of novel chitinase inhibitors with a scaffold of dipyridopyrimidine-3-carboxamide. Journal of Agricultural and Food Chemistry. 2020, 68(47):13584-13593.