科研成果

一、科研获奖

1. 王永奇,药用山茶属植物的现代化研究,教育部自然科学二等奖,2012,(证书编号:2011-082

2. 迟乃玉,菇渣海洋微生物转化技术,辽宁省技术发明奖二等奖,2012,(证书编号:2012F-2-01-01

3. 迟乃玉,废弃菇渣高附加值转化技术及其应用,辽宁省技术发明奖二等奖,,2010,(证书编号:2010F-2-01

4. 高凤山,辽宁特色品种荷包猪SLA-Ⅰ分子进化背景及应用研究,辽宁省技术发明三等奖,2015,(证书编号:2015F-1-01

5. 王永奇、冯宝民、史丽颖,东西北产藏药荨麻属植物现代化研究,辽宁省自然科学奖三等奖,2012,(证书编号:2012Z-3-03

6. 冯宝民,三种十字花科植物种子药用价值研究及其应用,大连市二等奖,2016,(证书编号:2014-2015-F-2-02-01

7. 李晓艳,絮凝动态膜和二氧化氯协同优化处理压载水机理研究,大连市科技进步一等奖,第二单位,参与,2016,(证书编号:2014-2015-J-1-07-02

8. 高凤山,辽宁特色品种荷包猪SLA-Ⅰ分子进化背景及应用研究,大连市技术发明一等奖,2014,(证书编号:2013F-1-03

9. 姚子昂、吴海歌,系列卡拉胶寡糖的酶法制备技术及生产工艺,国家海洋局海洋科学技术二等奖,2013,(证书编号:HKJ2013-G-2-A32-02

10. 迟彦,紫杉醇产生菌现代分子生物学选育及发酵工艺的研究,黑龙江省科学技术进步二等奖,第二单位,参与,2012,(证书编号:2012-034-05

二、专利

1.        高凤山,许崇波. 荷包猪SLA-2基因及其应用,20大连大学,国家发明专利,ZL201010545194.5

2.        高凤山. 一种O型口蹄疫CTL表位肽及筛选方法,大连大学,国家发明专利ZL201310742940.3

3.        高凤山,白婧. 荷包猪SLA-1基因及其应用,大连大学, 国家发明专利,ZL201010545216.8

4.        吴海歌. 一种单细胞海带粉及海带寡糖的制备方法,大连大学,国家发明专利ZL201410040785.5

5.        高凤山,乔翠,赵德,冯磊.荷包猪SLA-3基因及其应用,大连大学, 国家发明专利,ZL201110448521X

6.        高凤山. 一种A型口蹄疫CTL表位肽及筛选方法,大连大学, 国家发明专利,ZL201310746389.X

7.        史丽颖,于大永. 一种金花茶黄酮苷及其制备方法和用途,大连大学,国家发明专利ZL 201410206858.3

8.        冯宝民,丁韵,王惠国,卢轩,秦海宏,陶刚,刘旭. 芥子碱氯化盐的制备方法及其医药应用,大连大学,国家发明专利,ZL201210436834.8

9.        冯宝民,王惠国,王永奇.一种镇咳作用有效成分-对羟基苯乙腈的制备方法,大连大学, ZL200910010744.0

10.     侯义龙. 甜樱桃品种晚红珠的离体再生方法,大连大学,国家发明专利,ZL201410137151.1

11.     卢轩、冯宝民、王惠国、秦海宏、李博、靳元春. 分段式高效装柱可调节柱温可自由分拆的柱层析组合装置,大连大学,国家发明专利,ZL 201410316314.2

12.     冯宝民,卢轩,王惠国,张玲玲,李博,程兴华. 一种高效智能自动展开装置及其使用方法,大连大学,国家发明专利,ZL 201410337495.7

13.     李倩. 旋转内循环气升式膜生物反应器及其工艺系统,大连大学,国家发明专利,ZL 201410788068.0

14.     李倩. 模块拼装式移液器枪头盒(授权专利)大连大学,国家发明专利,ZL 201510333447.5

15.     唐玲,王洋,占希. 一种用于肝硬化治疗的药物组合物及其用途,大连大学,国家发明专利,ZL201410342881.5

16.     唐玲,王姣. 一种用于镇痛的药物组合物及其用途,大连大学,国家发明专利,ZL201410344544.x

17.     唐玲,叶立强,王姣. 从油茶皂素中分离的化合物的抗癌作用,大连大学,国家发明专利,ZL2013105906427

18.     唐玲,王姣. 从油茶皂素中分离化合物的方法,大连大学,国家发明专利,ZL2013105886599

19.     曹阳,付爽,赵捷,杨超,霍晋彦. 鳞翅目昆虫塑化标本制作方法,大连大学,国家发明专利,ZL201410178549X

20.     曹阳,赵捷,付爽,杨超,霍晋彦. 小型海洋动物塑化标本制作方法,大连大学,国家发明专利,ZL201410178931.0

21.    张庆芳,迟乃玉,马莉. 微生物发酵生产低温蛋白酶的方法,大连大学,国家发明专利,ZL201010162644.2

22.    张庆芳, 迟乃玉, 王鑫.微生物发酵生产低温淀粉酶的方法, 国家发明专利,

    ZL201010162660.1.

23.    张庆芳, 迟乃玉, 孙子羽,冯旭明. 微生物发酵生产低温生淀粉糖化酶的方法,大连大学,国家发明专利, ZL201010162658.4.

24.    张庆芳, 迟乃玉, 窦少华,于爽. 微生物发酵生产低温脂肪酶的方法, 大连大学,国家发明专利,  

    ZL201010162740.7.

25.     张庆芳,迟乃, 窦少华, 陈璨.微生物发酵生产低温植酸酶的方法, 大连大学,国家发明专利, ZL201010162606.7.

26.     刘庆平,迟彦,张应彪,李文哲. 一种具有预防治疗动脉粥样硬化作用的蛋白的表达、纯化及应用,大连大学,国家发明专利,ZL 2009 1 0187943.9

27.     刘庆平,迟彦,于田田,李敬达,王仁军. 一种重组蛋白功能结构域抑制巨噬细胞组织因子表达及其用途,大连大学,国家发明专利,申请号:201511008430.9

28.    董晓宇, 袁玉莲, 迟乃玉,朱晓丽, 修志龙. 一种新型生物反应器, 大连大学,国家发明专利,ZL201110295764.4.

29.    张庆芳,迟乃玉,窦少华,于爽.微生物发酵生产低温脂肪酶的方法,大连大学,国家发明专利,ZL201010162740.7

30.     张庆芳,迟乃玉,窦少华,陈璨.微生物发酵生产低温植酸酶的方法,大连大学,国家发明专利,ZL201010162606.7

31.     于大永,史丽颖,冯宝民,王永奇,一种金花茶黄酮苷及其制备方法和用途,大连大学,国家发明专利,ZL201210045032.4

32.  秦海宏,程兴华,王惠国,卢轩,张玲玲.便携式恒温抑菌增湿智能控制的组合吸氧装置,大连大学,国家发明专利,ZLCN201410337089.0.

33.  王惠国,秦海宏.具有益气养血安神催乳的中药复方制剂及其制备方法和应用,大连大学,国家发明专利ZL201310349964.2.

34.     魏磊、冯宝民、卢轩、王惠国、赵小红、李雪清、张楠楠、杜春涛. 一种配液装置,大连大学,实用新型专利,ZL 201620060580.8

35.     王惠国. 一种多功能医用床垫床单组合装置,大连大学,实用新型专利,ZL 201520953788.8

36.  李博,冯宝民,王惠国,卢轩,秦海宏,程兴华.一种高效装柱可调节柱温可自由分拆的柱色谱组合装置,大连大学,实用新型专利ZL201420367490.4

37.     王惠国,冯宝民.一种多功能呼吸环境模拟及吸入性造模、给药装置,大连大学,实用新型专利,ZL200920013794.X.

38.  秦海宏,王惠国,赵小红,张楠楠.多功能医用床垫床单组合装置,大连大学,国家发明专利,申请号201510834038.3

39.  卢轩,李雪清,程兴华,王惠国,于大永,冯宝民.裂木脂素类化合物—荨麻裂环木脂素苷E及其制备方法,大连大学,国家发明专利,申请号201510890039.X.

40.  姚子昂;吴海歌;赵博闻;崔红利.以海洋细菌为来源获取的κ-卡拉胶酶基因及重组酶制备方法,大连大学,国家发明专利,申请号201610503827.3

三、论文(以近5年的SCIEI等为主)

1.        Zong-Xia YuLing-Jian Wang, Bo Zhao, Chun-Min Shan, Yu-Hua ZhangDong-Fang Chen, Xiao-Ya Chen*. Progressive regulation of sesquiterpene biosynthesis in Arabidopsis and Patchouli (Pogostemon cablin) by the miR 156-targeted SPL transcript factors. Mol Plant. 2015, 8(1):98-110.

2.        Liu YQ, Han XF, Bo JX, Ma HP. Wedelolactone Enhances Osteoblastogenesis but Inhibits Osteoclastogenesis through Sema3A/NRP1/PlexinA1 Pathway. Frontiers in Pharmacology, 2016, 7(183)375.

3.        Y. Chi, T. Yu, Q. Liu, J. Qin, J. Li, Y. Chen, M. Li. Recombinant domain V of beta(2)-Glycoprotein I inhibits oxldl-induced TF expression in macrophages. Atherosclerosis 2016, 252:e171.

4.        Li-Hua Zhang, Bao-Min Feng, Gang Chen, Sheng-Ge Li, Yi Sun, Hong-Hua Wu, Jiao Bai, Hui-Ming Hua, Hai-Feng Wang, Yue-Hu Pei. Sporulaminals A and B: a pair of unusual epimeric spiroaminal derivatives from a marine-derived fungus Paraconiothyrium sporulosum YK-03, RSC Advances, 2016, 6:42361-42366.

5.        Dayong Yu*,Xiuxiu Yang, Xuan Lu, Liying Shi, Baomin FengEthyl acetate extract of Peperomia tetraphylla induces cytotoxicity, cell cycle arrest, and apoptosis in lymphoma U937 cellsBiomedicine & Pharmacotherapy 2016841802-1809.

6.        Li-Hua Zhang, Bao-Min Feng, Yi Sun, Hong-Hua Wu, Sheng-Ge Li, Bing Liu, Fang Liu, Wei-Yang Zhang, Gang Chen, Jiao Bai, Hui-Ming Hua, Hai-Feng Wang, Yue-Hu Pei Flaviphenalenones A-C, three new phenalenone derivatives from the fungus Aspergillus flavipes PJ03-11, Tetrahedron Letters, 2016, 57: 645-649 .

7.        Li-Hua Zhang, Bao-Min Feng, Yu-Qing Zhao, Yi Sun, Bing Liu, Fang Liu, Gang Chen, Jiao Bai, Hui-Ming Hua, Hai-Feng Wang, Yue-Hu Pei. Polyketide butenolide, diphenyl ether, and benzophenone derivatives from the fungus Aspergillus flavipes PJ03-11, Bioorganic & Medicinal Chemistry Letters, 2016, 26: 346-350 .

8.        Kun Li, Meichen Wang, Yaping Hu, Na Xu, Qin Yu, Qinfu Wang* TAK1 negatively regulates lipopolysaccharide-induced proinflammatory cytokines production in myeloid cells, Cellular Immunology, 2016310193-198http://dx.doi.org/10.1016/j.cellimm.2016.09.011.

9.        Jia Liu, Wei Li, Huan Liu, Yaping Hu, Peng Wang, Zhengyi Zhang, Qinfu Wang*,  Poly(lactic-co-glycolic acid) nanoparticles with entrapped live vaccine  improve cellular immunity against porcine reproductive and respiratory syndrome virusBasic & Clinical Pharmacology & Toxicology, 2016; 119 (suppl. 2): 1-35 .

10.     Yaping Hu, Meichen Wang, Xuemei Zhang, Peng Wang, Huan Liu, Qinfu Wang*. Heterogeneity of swine lung macrophages inoculated by porcine reproductive and respiratory syndrome virus. Food & Agricultural Immunology, 2016: p. 1-10.

11.     Nan Jiang*Lijun HuChaonan LiuXueli GaoShimin Zheng. 60S ribosomal protein L35 regulates β-casein translational elongation and secretion in bovine mammary epithelial cells. Archives of Biochemistry & Biophysics, 2015. 583: p. 130-139.

12.     Liu YQ*, Han XF, Cheng MC, Xiao HB. A cell-based model of bone remodeling for identifying activity of icarrin in the treatment of osteoporosis. Biotechnol Lett, 2015, 37(1): 219.

13.     Hong-Yu CaoYan-Wei LiuQian TangJi-Min ZhaoXiang-Jin GuoXue-Fang Zheng*. Spectroscopic insights into the Photoreduction of Cytochrome c with UVA-Vis Light Irradiation. Protein Pept Lett, 2015. 22(9): p. 853-9.

14.     Yan ChiLe WangYuanyuan LiuYanhua MaRenjun WangXiaofei HanHui QiaoJiabin LinEiji MatsuuraShuqian LiuQingping Liu*. 7-Ketocholesteryl-9-carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages. Atherosclerosis, 2014. 234(2): p. 461-8.

15.     Li J, Chi Y, Liu S, Wang L, Wang R, Han X, Matsuura E, Liu Q*. Recombinant domain V of β2-glycoprotein I inhibits the formation of atherogenic oxLDL/β2-glycoprotein I complexes. Journal of Clinical Immunology, 2014. 34(6): p. 669-76.

16.     Lei Feng, Mingwei Sun, Song-peng Dong, Feng-shan Gao*. Progress in crystallization of major histocompatibility complex class I in vertebrates. Science Bulletin, 2014. 59(12): p. 1308-1316.

17.     Dong Xiaoyu. Enhanced Membrane Permeability of Saccharomyces cerevisiae Induced by Dielectric Barrier Discharge Plasma at Atmospheric Pressure. Advanced Materials Research, 2014. 1033-1034: p. 229-235. (EI)

18.     Dong Xiaoyu*, Yuan Yulian, Tang Qian, Dou Shaohua, Di Lanbo, Zhang Xiuling. Parameter Optimization for Enhancement of Ethanol Yield by Atmospheric Pressure DBD-Treated Saccharomyces cerevisiae. 等离子体科学和技术(英文版), 2014. 16(1): p. 73-78.

19.     Feng-shan Gao*, Lei Feng, Qiang Zhang, Ruo-qian Yan, Yun-gang Li, Xin-sheng Li. Immunogenicity of Two FMDV Nonameric Peptides Encapsulated in Liposomes in Mice and the Protective Efficacy in Guinea Pigs. PLOS ONE, 2013, 8(7):e68658

20.     Han XF*, Xiao HB, Liu QP, Zhang LX, Yang QX, Zhao N, Liu RH, Wang XJ. Determination of Plasma Amino Acid Biomarkers by High Performance Liquid Chromatography for Diagnosis of Type 2 Diabetes Mellitus. Analytical Letters, 2013. 46(18): p. 2813-2827.

21.     Zi-ang Yao, Fei-fei Wang, Zheng Gao, Li-ming Jin, Hai-ge Wu*. Characterization of a κ-Carrageenase from Marine Cellulophaga lytica strain N5-2 and Analysis of Its Degradation Products. International Journal of Molecular Sciences, 2013. 14(12): p. 24592-602.

22.     Zi-ang Yao*, Hai-ge Wu, Sheng-xia Zhang, Yu-guang Du. Enzymatic preparation of κ-carrageenan oligosaccharides and their anti-angiogenic activity. Carbohydrate Polymers, 2014. 101(Complete): p. 359–367.

23.     Zi-ang Yao, Xu Ling, Hai-ge Wu. Immunomodulatory Function of κ-Carrageenan Oligosaccharides Acting on LPS-Activated Microglial Cells. Neurochemical Research, 2014. 39(2): p. 333-43.

24.     Feng-shan Gao*, Jing Bai, Xie-jie Gong, Xing-hui Zhang, Wen-jun Zhang, Dan Guo, Sheng Zhang. Analyzing the genetic characteristics and function of the swine leukocyte antigen 2 gene in a Chinese inbreed of pigs. Microbiology and Immunology, 2012. 56(3): p. 208-15.

25.     Feng-shan Gao*, Jing Bai, Qiang Zhang , Chong-bo Xu, Yanmin Li. Construction of multiple recombinant SLA-I proteins by linking heavy chains and light chains in vitro and analyzing their secondary and 3-dimensional structures. Gene, 2012. 502(2): p. 147-153.

26.     Feng-Shan Gao*, Chong-bo Xu, Xing-hui Zhang, Wen-jun Zhang, Dan Guo, Sheng Zhang. Analysing molecular characteristics of the SLA-1 gene from Chinese Hebao pigs. Journal of Genetics, 2012. 91(2): p. 219-221.

27.     Peng XYu DYFeng BMWang YQShi LY*. A new acylated flavonoid glycoside from the flowers of Camellia nitidissima and its effect on the induction of apoptosis in human lymphoma U937 cells. 2012. 14(8): p. 799-804.

28.     Xu Ling, Zi-ang Yao, Hai-ge Wu*, Fei-fei Wang, Sheng-xia Zhang, The immune regulation of κ-carrageenan oligosaccharide and its desulfated derivatives on LPS-activated microglial cells. Neurochemistry International, 2012. 61(5): p. 689-96.

29.     Baomin Feng, Haihong Qin, Huiguo Wang, Liying Shi, Dayong Yu, Baoquan Ji, Qi Zhao, Yongqi Wang. Three new secolignan glycosides from Urtica fissa E. Pritz. Journal of Natural Medicines, 2012. 66(3): p. 562-5.

30.     Li W, Liu Q, Pang Y, Jin J, Wang H, Cao H, Li Z, Wang X, Ma B, Chi Y, Wang R, Kondo A, Gu J, Taniguchi N. Core fucosylation of mu heavy chains regulates the assembly of precursor B cell receptors and its intracellular signaling. Journal of Biological Chemistry, 2011.

31.     唐乾, 史珊珊, 曹洪玉, 郭相金, 张涛, 郑学仿*.细胞色素CNO的反应机制. 无机化学学报, 2015, 31(8):1511-1519. (SCI IF=0.87)

32.     董晓宇, 刘婷婷, 窦少华, 唐乾, 袁玉莲, 王晓辉, 王仁军, 焦鑫艳, 郭相金. 大气压介质阻挡放电等离子体强化克雷伯氏菌发酵的研究. 高校化学工程学报, 2015. 29(4): p. 881-889. (EI)